|Op. System:||Windows All|
|File size:||3.61 MB|
|Publisher:||University of Oxford|
Publisher description for HOMA Calculator
The Homeostasis Model Assessment (HOMA) estimates steady state beta cell function (%B) and insulin sensitivity (%S), as percentages of a normal reference population. These measures correspond well, but are not necessarily equivalent, to non-steady state estimates of beta cell function and insulin sensitivity derived from stimulatory models such as the hyperinsulinaemic clamp, the hyperglycaemic clamp, the intravenous glucose tolerance test (acute insulin response, minimal model), and the oral glucose tolerance test (0-30 delta I/G).In 1976, Robert Turner and Rury Holman developed the concept that fasting plasma insulin and glucose levels were determined, in part, by a hepatic-beta cell feedback loop [Abstract]. They postulated that elevated fasting glucose levels reflected a compensatory mechanism that maintained fasting insulin levels when there was a reduced insulin secretory capacity, and that fasting insulin levels were elevated in direct proportion to diminished insulin sensitivity. A mathematical feedback model based on these hypotheses was constructed to estimate the degrees of beta cell function and insulin sensitivity that would equate to the steady state plasma glucose and insulin levels observed in an individual [Metabolism 1979; 28:1086-96].